Imagine one day, you are sitting down with your kid and then you guys start watching a movie... the kid sees a old (or what will likely be referred to as a “aged”) person, and then the kid believes it’s just science fiction because there’s no old people.
I look forward to watching this video 120 years from now.
As a British person, I’m happy to say that ageing isn’t an issue, as were all clones that are birthed by queen Elizabeth II like a queen bee
Living longer is nice and all, but I'd argue what's really desirable is prolonging youth. Like if you live to 150 that's good, but if you live to 150 and you're in mid-40s condition in your mid-80s that'd be really something special.
This is why Tom Scott has simultaneously looked 26 and 45 for the past fifteen years
If we ultimately die after 150 years, then I wouldn't say we have cured aging. Sure we can possibly live longer and healthier with these interventions, but we can't say that we have cured aging. Curing aging means becoming biologically immortal (though you could still die from accidents, lack of food, lack of oxygen, etc).
There’s a scientist called Aubrey DeGrey (I think?) who has been trying to get us to understand this concept: Ageing as a disease, to be cured. I saw him on a BBC talk show (sort of light, comedy show) where they asked the audience, “Who would want to live to 200, raise your hands?” Hardly anyone did. Until he explained, “What if you lived to 200, but looked and felt like a 30 year old that whole time.” Of course, all of them wanted that. But it seems that there are so many false assumptions and misunderstandings around the idea of ageing, that science has its work cut out, just explaining the notion of treating ageing as the disease, to be cured?
imagine in the future, a 250 years old young man looks at his great great great great grandpa photo and wonder, "why he is so wrinkly in his 70s"
I'd really enjoy aging being slowed or reversed in my life time. I'm only 29, but the march of time haunts me every day, and is debilitating for my mental health. However, if past science is any indicator, something can be discovered but not acknowledged or used until many years later.
Great video man! Just one thing, sirtiuns are very over-hyped, and the explanation of them leaving the histones doesn't really hold water. In fact, many histone deacetylase inhibitors have been found to slow aging. I cannot see a way that increasing HDAC activity prolongs lifespan, as it will lead to greater geneteic silencing. The reason NMN/NR work is because they increase NAD+, not sirtiuns. As for Sinclair, he sold his sirtiun pharma biz for a lot of money, but in the end it was canned due to higher rates of cancer in those taking stilbenoid derivatives, like resveratrol, than placebo.
Finding ways to keep cancers at bay while we combat aging will certainly be a tricky endeavor. Thankfully aging related cancers shouldn’t be as much of a deal to worry about, but living longer may pose cancer as an inevitability.
Quite amazing. As a blenderer myself I can imagine the time and effort that goes into these videos let alone researching the topic and writing the script. I'll have to watch it a few times to fully grasp it. The optimism at the end was heartening. It's great your channel is growing and merry xmas to you.
I always had trouble accepting when in fictions they try to show the wants of being immortal to be a hard thing. Glad I'm not alone
I got a feeling when they finally figure it out (I doubt in my lifetime or budget) they will be like "Of course, the answer was there all along. How did we not solve this sooner?"
"I'm Mr. Meeseeks, look at me!" "Help me do live examples of degenerative diseases" "Can do!"
This reminds me about learning more on Microneedling. It is a odd yet "Natural" way to repair something damages by damaging it so lightly it "Double fixes" itself. Like fixing something that was never broken.
Honestly, the perception of disease needs to change. Diseases are conditions as a result of some or many biological conditions going wrong. Diabetes is a disease involving insulin going wrong, but may be caused by a variety of ways of losing insulin production OR body not using insulin correctly (insulin resistance), and it's all called diabetes. Aging could be similar, a disease with various onsets not pinpointed by a single factor.
As a transhumanist and a neuroscientist I deeply believe that aging and death are a terrible disease and every effort should be put into finding a cure for them.
We're crowdsourcing the cure for aging. Great video!
@cooler-ian