@charvyr

Great video, quite detailed surprisingly, except for at 11:12 - the mechanism of one-hit vulnerability of TP53 is NOT a 'not fully understood mechanism'. It is due to hetero-oligomerization of the wild type p53 protein with the mutant p53 protein that results in the dominant negative effect of a single mutation in this tumour suppressor gene. I understand it might be difficult to include this aspect in the video but it is a well known phenomenon, so saying otherwise seems misleading.
References: 
Lane DP. p53, guardian of the genome. Nature. 1992;358(6381):15-16. doi:10.1038/358015a0.
Brosh R, Rotter V. When mutants gain new powers: News from the mutant p53 field. Nat Rev Cancer. 2009;9(10):701-713. doi:10.1038/nrc2693

@therelaxafterrevision8073

can't believe you used the real protein structures, that's astonishing attention to detail

@albert_the_cool8092

these videos are huge, like the production level is insane as always, keep up the good work!
again thank you for these and have a great one!

@nathanb011

Your body is actually pretty good at finding and eliminating cancer. It's the ones that your body doesn't detect, that spread fast enough to be harmful but slow enough to not burn out, that jump between different types of cells, that are dangerous. And yet, all these minuscule on minuscule on minuscule chances cancel out with the number of cells just right so that it's on a human scale.

@BS-bd4xo

How can a simple educational channel be soooo good!! This is mindblowingly unboring!

I just love the animantions! And the topics will always keep me hooked. This channel deserves 1 million subs :)

@TheLifeFruit

Its astounding to see the quality of these videos. The sheer amount of detail is incredible. Thank very much for all of your hard work.

@justindie7543

Great video! But using the paper at 1:52 to claim that we go from 500 mutations per cell as an infant to 3000 per cell as an adult is confounded by the fact that they only looked at B cells. B cells are unique immune cells because they are able to select themselves to detect antigen by mutagenizing themselves, and the B cell receptor locus goes through 10k to 100k times more mutation than normal...so it's probably not the best cell type to use to make this claim.

@blenderfoto

Really enjoyed working with you on this video, thank you for the opportunity!

@sgerardpandian

Man you are one of the channels I click immediately no matter what the upload is about! Your explanatory and animation skills are off the charts and I can listen to you all day long! you deserve a billion subscribers, everyone should go through at least a couple of your vids, the content is so rich and diverse!

@-OBJ

This channel is criminally undersubed

@juliankandlhofer7553

all those tiny molecular robots grinding a way day after day just so I can watch this video and not have cancer. thanks tiny robots :) awesome video as always!

@PedanticNo1

I really love the style and content of your work.  Please don't stop if you can comfortably keep it up, I'm sure the rest of your audience feels exactly the same.

@REDandBLUEandORANGE

Absolutely breathtaking 
Your videos are the best on YouTube 

The attention to detail, the lack of watering down, your examples, everything makes these videos beautiful

@KarlMarcus8468

Always makes my day when a new But Why video comes out. Thanks for the awesome content.

@OldestHouse

such an underrated channel :( 

dont stop producing such content and i promise you you will explode one day!

@Asterism_Desmos

It feels like he has a doctorate in every subject, and still is very happy to teach.

@samluciano7716

Absolutely incredible video, love your channel

@gumball1216

I love these videos. Your clear and concise explanations paired with the very fun yet amazingly detailed animations make these videos a pleasure to watch. I can’t wait until the next one!

@MrDaraghkinch

"Chemistry is simply the interaction of charges." Wow

@lucascsrs2581

This channel is an undiscovered treasure. If you create a Patreon, I am in for sure.